Sleep Apnea, Subarachnoid Hemorrhage
Conditions
Keywords
Subarachnoid hemorrhage, Sleep Apnea
Brief summary
In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
Detailed description
Patients admitted with non-traumatic SAH will be consented and screened for sleep apnea within 48 hours after hospital admission. Blood pressure and clinical outcome will be monitored throughout ICU treatment and hospital stay, respectively. Diagnosis of sleep apnea will be confirmed on follow-up 3-6 month after SAH by sleep apnea screening (portable cardiorespiratory monitoring and out-of-center polysomnography, respectively).
Interventions
DEVICESleep Apnea Screening (Out of Center Polysomnography Device)
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subarachnoid Hemorrhage (Hunt & Hess 1 to 4) * \> 18 years of age * Ability to consent for study of healthcare proxy able to confirm patient will to participate
Exclusion criteria
* Stoke within 3 month prior to admission * Intubation prior or within 24 hours after admission * no healthcare proxy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to blood pressure target | Within 10 Days of hospital admission with subarachnoid hemorrhage | The time required to reach blood pressure target as defined by care provider. |
| Medication needed to achieve blood pressure target | Within 10 Days of hospital admission with subarachnoid hemorrhage | Blood pressure medication required to reach blood pressure target as defined by care provider. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in modified ranking scale (mRS) from baseline to discharge and follow-up visit, respectively. | 3 to 6 Month after SAH | Change in modified ranking scale at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. |
| Change in NIH stroke scale score (NIHSS) from admission to discharge and follow-up visit, respectively. | 3 to 6 Month after SAH | Neurological outcome measured as score in NIHSS at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. |
| Barthel Index at discharge at follow-up visit, respectively. | 3 to 6 Month after SAH | Impairment of daily living (score in Barthel index) at discharge and at follow-up visit (3 to 6 month after SAH) will be assessed. The change from baseline to discharge/follow-up will be compared between groups. |
Other
| Measure | Time frame |
|---|---|
| Incidence of Sleep Apnea in Patients with Subarachnoid Hemorrhage | 6 Month after SAH |
Countries
Germany
Contacts
Primary ContactSebastian Zaremba, MD
Backup ContactErdem Gueresir, MD, PhD
Outcome results
None listed