Comparative Study of Two Embryo Culture Systems

Comparative Study of Two Embryo Culture Systems: Randomization of Attempts at In Vitro Fertilization With ICSI at the Centre for Medically Assisted Procreation at Dijon CHU

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02722252

Acronym

INCUBATE

Enrollment

388

Registered

2016-03-29

Start date

2014-08-27

Completion date

2017-03-29

Last updated

2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

In Vitro Fertilization with ICSI

Brief summary

The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems. Indeed, these two systems, available in only two MAP centres in France, make it possible to maintain a stable temperature and gaseous environment during the in-vitro development of the embryos. It is necessary to observe the development of the embryos to determine which embryos have the highest implantation potential. These observations are done from time to time by microscope for one system and continuously using an incorporated video camera for the other (cinematographic study). The MAP centre in Dijon wishes to compare the interest of these two systems.

Interventions

DEVICEEmbryoscope

DEVICEEmbryo culture system without incorporated camera

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Persons who have provided oral consent * Attempt at In Vitro Fertilization with ICSI (IntraCytoplasmic Sperm Injection) * At least 6 mature ovocytes to microinject

Exclusion criteria

* Persons not covered by national health insurance * Attempt at In Vitro Fertilization (IVF) * Fewer than 6 mature ovocytes * Decision to transfer at the zygote stage during the multidisciplinary meeting * Attempts made in a context of viral risk (both systems are in a virus risk-free zone) * Attempts with surgically-harvested spermatozoa

Design outcomes

Primary

Measure	Time frame	Description
Implantation rate	16 weeks after transfer	The implantation rate is defined as the number of embryos implanted (gestational sacs seen on the US scan) compared to the total number of embryos transferred.

Secondary

Measure	Time frame
Rate of miscarriages	16 weeks after transfer

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026