Graves' Ophthalmopathy, Hypercholesterolemia
Conditions
Brief summary
The investigators have recently observed retrospectively that the occurrence of Graves' Orbitopathy in patients with Graves' disease is less frequent in patients with normal cholesterol levels, in line with another recent observation suggesting that statins play a protective role in Graves' patients from developing Graves' Orbitopathy. The present study is designed in order to investigate the possible association between Graves' Orbitopathy and high cholesterol level as well as the relation between Graves' Orbitopathy degree and high cholesterol level
Interventions
OTHERNo intervention
No intervention
Sponsors
University of Pisa
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Graves' disease with Graves' Orbitopathy 2. Graves' disease without Graves' Orbitopathy
Exclusion criteria
1. Previous treatment with radioiodine 2. Previous treatment with thyroidectomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between LDL cholesterol levels and Graves' Orbitopathy | Baseline | Relationship between the levels of LDL cholesterol and the presence of Graves' Orbitopathy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between LDL cholesterol levels and the activity of Graves' Orbitopathy | Baseline | Relationship between the levels of LDL cholesterol and the Graves' Orbitopathy clinical activity score |
| Relationship between LDL cholesterol levels and the severity of Graves' Orbitopathy | Baseline | Relationship between the levels of LDL cholesterol the Graves' Orbitopathy severity score (NOSPECS score) |
Countries
Italy
Outcome results
None listed