COPD, Myocardial Diseases
Conditions
Keywords
Troponin, Exercise
Brief summary
The primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin T, in patients with COPD.
Detailed description
Patients with COPD will perform a cardiopulmonary exercise test (CPET) on treadmill until exhaustion, 8-12 minutes. Venous blood will be drawn before exercise test and 15 minutes, 3 hours and 24 hours after test for analysis of high sensitive Cardiac troponin T (hs-cTnT). The investigators will also measure arterial bloodgas, oxygen uptake, carbon dioxide consumption, ventilation, blood pressure, ECG, heart rate and ask for dyspnea-score.
Interventions
DEVICETreadmill exercise test
Patients are subjected to an incremental exercise test to exhaustion on a treadmill
Sponsors
LHL Helse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* COPD * GOLD 2-4 * BODE-index ≥ 2 * Referred by physician to a CPET
Exclusion criteria
* Other serious pulmonary diseases (e.g. cancer, sarcoidosis, restrictive pulmonary diseases) * Chronic heart disease with unstable angina or myocardial infarction ≤ 3 months prior to inclusion * Percutaneous coronary intervention (PCI) * Hypertension that is not controlled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin T concentration 3 h | 3 h |
Countries
Norway
Outcome results
None listed