Aging, Obesity
Conditions
Brief summary
This study plans to learn more about how age and weight impact appetite and food intake. Specifically, this study is being done to see whether age and obesity impact appetite and the brain's response to food. In this study the investigators will be evaluating how participants brains respond to food images as well as your food-related behaviors and hormones. The investigators will be comparing older individuals aged 65 to 85 years who are normal weight compared to those who are obese. The Investigators will then compare older aged individuals to younger adults aged 21 to 45 years.
Detailed description
In a cross sectional design participants will be studied on one occasion after a 3-day diet run-in. On the study day they will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken and appetite measures performed. Participants will then undergo functional magnetic resonance imaging (fMRI). This will be followed by a breakfast meal. Blood and appetite measures will be performed every half hour for 3 hours. Repeat fMRI will be performed 30 minutes after the meal. After three hours participants will be offered a buffet style lunch and then will be done with the study visit.
Interventions
DIETARY_SUPPLEMENT3-day diet Run-in
Participants will be studied on one occasion after a 3-day diet run-in. This will be followed by a breakfast meal.
PROCEDUREfMRI
After a 3-day diet run-in, participants will undergo a functional magnetic resonance imaging procedure (fMRI). Repeat fMRI will be performed 30 minutes after the meal.
PROCEDUREIntravenous catheter placed for blood draws
On the study day participants will present in the fasting state, have an intravenous catheter placed for blood draws and have baseline blood samples taken. Blood and appetite measures will be performed every half hour for 3 hours.
Sponsors
University of Colorado, Denver
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Older aged adults (O): 65-85 * Younger adults (Y): 21-45 * Obese (Ob): body mass index (BMI) 30-40 * Normal Weight (NW): BMI 18-25
Exclusion criteria
* Pregnancy; * Advanced organ failure; * Active cancer diagnosis; * Uncontrolled hypertension or metabolic disorder; * Cognitive impairment or psychiatric disease limiting ability to comply; * Presently in an exercise or diet program; * Recent weight loss of \>5 lbs in past 6 mo.; * Bariatric surgery; * Use of any weight loss drugs; * Use of any medication known to significantly affect appetite (anti-depressants are allowable); * Present tobacco use; * Use/abuse of substances of abuse including any marijuana use by history; * Any contraindication to MRI; * Claustrophobia; * Body weight \>300 lbs; and * Inability to fit in MRI scanner.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neuronal response to food images | 1 day | fMRI of brain will be done in response to images of food |
Countries
United States
Outcome results
None listed