Atrial Fibrillation
Conditions
Brief summary
The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.
Interventions
PROCEDURELinear ablation in addiction to circumferential pulmonary vein isolation
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with persistent Atrial fibrillation (20\ 80 years) * LA diameter \<55mm * patients possible to anticoagulation and anti arrhythmic drug
Exclusion criteria
* Structural cardiac disease * Contraindication to brain perfusion CT * Catheter ablation history for AF, * Cardiac surgery for AF * active internal bleeding * Impossible to anticoagulation or antiarrhythmic drug * valvular AF (MA\> GII, Mechanical valve, Mitral valve replacement) * Patients with severe medical disease * Expected survival \< 1year * Severe alcoholics, drug addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence of atrial fibrillation after catheter ablation | 12 month |
Secondary
| Measure | Time frame |
|---|---|
| procedure time | 1 day |
| procedure related complication rate | 12 month |
| rate of hospitalization | 12 month |
Countries
South Korea
Outcome results
None listed