Hypokalemia
Conditions
Brief summary
evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia
Detailed description
Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia. Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.
Interventions
OTHERKCl plus 0.9%NaCl
comparison of KCl plus 0.9%NaCl and KCl plus 0.45%NaCl for correction of hypokalemia
OTHERKCl plus 0.45%NaCl
comparison of KCl plus 0.9%NaCl and KCl plus 0.45%NaCl for correction of hypokalemia
Sponsors
Phramongkutklao College of Medicine and Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Serum K+ 2.5-3.49 mmol/L * No life threatening condition from hypokalemia
Exclusion criteria
* Pregnancy * Volume overload, heart failure * Hypotension * Acute kidney injury * Dysnatremia * K+ shift * Salt wasting nephropathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants with normal serum K as assessed by serum electrolyte | 24 hours |
Countries
Thailand
Contacts
Primary ContactTheerasak Tangwonglert, MD.
Outcome results
None listed