Colorectal Cancer, Gastric Cancer
Conditions
Brief summary
Standard 3+3 dose escalation design of TKI258/XELOX in advanced gastric/gastro-oesophageal and colorectal cancer.
Detailed description
This is a 3+3 dose escalation design with 4 pre-defined TKI258 dose levels (200mg, 300mg, 400mg and 500mg daily with 5 days on and 2 days off schedule) in combination with a fixed standard dose of XELOX (Capecitabine and Oxaliplatin) to establish the recommended phase 2 dose.
Interventions
DRUGTKI258
4 dose levels of TKI258: 200mg, 300mg, 400mg, 500mg once daily, 5days on and 2 days off;
DRUGXeloda,
Capecitabine (xeloda): 2000mg/m2, twice a day on Day 1-14;
DRUGOxaliplatin
Oxaliplatin: 130mg/m2 day 1 every 21days
Sponsors
Novartis
National Cancer Centre, Singapore
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients must have histologically confirmed gastric, gastro-oesophageal or colorectal adenocarcinoma. 2. The gastric or gastro-oesophageal cancer must be locally advanced unresectable or metastatic. Colorectal cancer must be metastatic and for which subsequent resection of all metastatic disease is assessed not to be feasible. 3. Age \>18 years. 4. Eastern Cooperative Oncology Group (ECOG) performance status \<2 (Karnofsky \>60%, see Appendix A). 5. Life expectancy of greater than 3 months 6. Patients must have normal organ and marrow function as defined below: * leukocytes \>3,000/mcL * absolute neutrophil count \>1,500/microliter (mcL) TKI258/XELOX phase 1 protocol version 3.3 Dated 30 November 2011 1 3 * platelets \>100,000/mcL * total bilirubin \<= 1.5 x upper limit of normal (ULN) * aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \<2.5 X institutional upper limit of normal * creatinine within normal institutional limits OR * creatinine clearance \>55 mL/min for patients with creatinine levels above institutional normal. 7. The effects of TKI258 and XELOX on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. 8. Baseline left ventricular ejection fraction (LVEF) \>= 50% 9. Ability to understand and the willingness to sign a written informed consent document.
Exclusion criteria
1. Patients are not considered to have a currently active malignancy if they have TKI258/XELOX phase 1 protocol version 3.3 Dated 30 November 2011 1 4 completed therapy and are considered to have a less than 30% risk of relapse. 2. Pregnant women are excluded from this study because of the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with TKI258 or XELOX, breastfeeding should be discontinued if the mother is treated with TKI258 or XELOX. 3. Patients with prior history of transient ischemia attack or cerebrovascular disease or prior history of ischemia heart disease or myocardia infarction and 2 or more risk factors: ever smoker with \> 30 packs per year exposure or on medication for diabetes mellitus or hypertension or hyperlipidemia. 4. In addition for the Beginning at dose expansion cohort, the following
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the recommended phase 2 dose of TKI258 in combination with XELOX (Capecitabine and Oxaliplatin) | 42 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Describe the toxic effects of TKI258 when administered in combination with XELOX chemotherapy. | one year | Toxicity will be graded using CTCAE version 4.0 |
| Measure the Area under the plasma concentration versus time curve (AUC) of TKI258 at specific timepoints | 42 days | — |
Countries
Singapore
Outcome results
None listed