Ischemic Stroke
Conditions
Keywords
RNF213 rs112735431 Gene, Acute Non-embolic ischemic stroke
Brief summary
To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.
Detailed description
This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.
Interventions
GENETICDNA sequencing
withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene
Sponsors
Chulalongkorn University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Nationality in Thailand * Age equal or more than 18 years * Clinical and imaging diagnosis of acute ischemic stroke * Patient consent to participate in the research
Exclusion criteria
* High risk for cardioembolic stroke by TOAST classification * Contraindication for venipuncture * Pregnancy or breast feeding patient * History of head and neck radiation * Down's syndrome * Marfan syndrome * Autoimmune disease such as SLE * Ongoing malignancy or remission of malignancy less than 1year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Participants With RNF213 rs112735431 Gene polymorphism | 1 year |
Countries
Thailand
Contacts
Primary ContactSuporn Travanichakul, MD
Outcome results
None listed