Valvular Heart Disease Patients
Conditions
Brief summary
Ischemic reperfusion injury of cardiopulmonary bypass and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing valvular heart surgery. The incidence of postoperative renal dysfunction was reported as high as 7\ 8% in heart surgery using bypass, and is thought to be caused by ischemia/reperfusion injury. Remote ischemic postconditioning was also reported to be protective for ischemic/reperfusion injury in previous animal studies and stoke patients. Therefore, the investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on postoperative renal dysfunction in subjects undergoing valvular heart surgery with bypass.
Interventions
PROCEDUREremote ischemic postconditioning
Remote ischemic postconditioning post group will take a remote ischemic postconditioning with tourniquet in their lower extremity under thigh. The conditioning is 5 minutes of inflation, and 5 minutes of deflation, repeated 3 cycles.
PROCEDUREvalvular surgery with bypass
valvular surgery with bypass
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients who are undergoing valvular heart surgery * Adult * age 19-80
Exclusion criteria
* peripheral vascular disease with circulation deterioration * Renal replacement therapy * preconditioning medication * Myocardiac infarction within 3 weeks * active infective endocarditis * high dosage steroid therapy * mental retardation * unlettered person
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative renal dysfunction using AKIN(acute kidney injury network) criteria | 5 days |
Countries
South Korea
Outcome results
None listed