Drug-Drug Interaction Study to Assess the Effects of Multiple-Dose Administration of K-877 on the Pharmacodynamics and the Pharmacokinetics of Multiple-Dose Administration of Warfarin in Healthy Adult Volunteers

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02719431

Enrollment

Registered

2016-03-25

Start date

2016-01-31

Completion date

2016-02-29

Last updated

2016-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The purpose of this study is to assess the effects of K-877 on the pharmacodynamics and the pharmacokinetics of warfarin in healthy adults volunteers.

Interventions

DRUGWarfarin

DRUGK-877

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Subject provides written informed consent before any study specific evaluation is performed. * Subject is a healthy adult male or female volunteer between the ages of 18 and 45 years, inclusive. * Subject has a body mass index of 18 to 30 kg/m², inclusive.

Exclusion criteria

* Subject has clinically relevant abnormalities in the screening or check in assessments. * Subject has clinically significant out-of-range PT, INR, activated partial thromboplastin time, fibrinogen, protein C, or protein S. * Subject has abnormal prolongation of skin bleeding time at Screening.

Design outcomes

Primary

Measure	Time frame
International normalized ratio (INR)	22 Days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026