Hemodynamics, Liver, Terlipressin
Conditions
Brief summary
To evaluate the effect of terlipressin infusion on systemic and hepatic hemodynamics during hepatobiliary surgery
Interventions
DRUGterlipressin
Terlipressin will be started at the beginning of surgery as an initial bolus dose of 1 mg over 30 mints(1 mg/50 ml normal saline at a rate of 100 ml/h) followed by a continuous infusion of 2 μg/kg/h(1 mg/50 ml at a rate equal to wt/10 ml per hour) and weaned in the postoperative period over 4 hours.
DRUGnormal saline
Patients receive 50 ml normal saline at a rate of 100 ml/h followed by a continuous infusion of 50 ml at a rate equal to wt/10 ml per hour and weaned in the postoperative period over 4 hours.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years. * Any gender. * ASA (American Society of Anesthesiologists) Classification( Class I-II) * Patients undergoing major elective hepatobiliary surgery.
Exclusion criteria
* Preoperative renal failure (GFR \< 50 ml/min). * Severe liver dysfunction (Child- turcotte -Pugh grade C). * Hyponatremia (\<132 mmol/l). * Severe aortic regurgitation, severe mitral regurgitation, heart failure. * Symptomatic coronary heart disease. * Bradycardic arrhythmia (heart rate \< 60/min). * Peripheral artery occlusive disease (clinical stadium II-IV). * Uncontrolled arterial hypertension (Blood pressure \>160/100 mmHg despite intensive treatment). * Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| portal pressure changes | intraoperative period | portal pressure changes in mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect on systemic vascular resistance | intraoperative period | •Effect on systemic vascular resistance in dyne.s/cm5 |
| Renal impairment | for 3 days in the postoperative period | Number of patients with renal impairment \[defined as at least a doubling of serum creatinine or oliguria (\<500 mL/24 hours)\]. |
| Blood units transfused | intraoperative period | Number of packed RBCs (red blood cells) units transfused |
Countries
Egypt
Outcome results
None listed