Infertility
Conditions
Keywords
KIR HLA-C, ART
Brief summary
Has the maternal KIR haplotype an impact in pregnancy, miscarriage and live birth rates per embryo transfer in donor oocytes -ART by paternal and oocyte donor HLA-C?
Detailed description
The combination of maternal KIR haplotype and parental, donors HLA-C, could predict which couple can benefit for the selection of single embryo transfer (SET)/double embryo transfer (DET), or donor selection by HLA-C in ART, in order to increase the live birth rate (LBR)/cycle since HLA-C1/C1 donors are predicted to be safer and C2/C2 males or oocyte donors may be mor dangerous as identified by epidemiological studies
Interventions
GENETICKIR HLAC determinations
We will take blood samples for KIR HLA-C determinations.
Sponsors
IVI Madrid
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 19 - 27 kg/m2 * Blastocyst embryo transfer previous. * Normal karyotype, thrombophylic and immunological results. * Normal clinical history, viral serology, hormonal analysis (TSH, T4, prolactin, estrogen, progesterone), spermiogram, sperm FISH and pelvic ultrasound results.
Exclusion criteria
* Pregnancy women. * Psychiatric disorders. * Uterus alterations. * Polycystic ovary syndrome * Genetic and autoimmune diseases. * Infectious diseases. * Corticoid and immunosuppressant treatments previous.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compatibility maternal fetal KIR HLA-C | 2 years | KIR haplotype regions will be defined by the presence of the following KIR genes: Cen-A/2DL3: Tel-A/3DL1 and 2DS4; Cen-B/2DL2 and 2DS2; Tel-B/2DS1 and 3DS1. The HLA-C ligands for KIRs will be divided into 2 groups: HLA-C1 and HLA\_C2 |
Countries
Spain
Outcome results
None listed