Squamous Cell Carcinoma of the Skin
Conditions
Keywords
squamous cell carcinoma, dermatosurgery, immunohistochemistry
Brief summary
Aim of the study is to verify wether it is possible to have a more sensitive diagnostic tool using pancytokeratin immunohistochemistry for desmoplastic squamous cell carcinoma compared to regular H&E staining. The investigators therefore plan to include 73 participants with a confirmed diagnosis of desmoplastic squamous cell carcinoma and do regular follow up.
Interventions
PROCEDUREImmunohistochemistry using Pancytokeratin Staining
Sponsors
University Hospital Tuebingen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* desmoplastic squamous cell carcinoma (SCC) of the skin
Exclusion criteria
* tumor recurrence * collision tumors * other skin malignancies * progeria * Rothmund-Thomson-Syndrome * lacking of the capacity for informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence free survival of patients with desmoplastic squamous cell carcinoma (SCC) diagnosed with immunohistochemistry . | 4 years |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of local recurrence with immunohistochemistry | 4 years |
| Histological pattern of tumour growth (continuous versus discontinuous) | 4 years |
| Dimension of the tumor spreading according to histological work-up (measured in mm) | 4 years |
| Presence of perineurial and perivascular tumor invasion according to histological work-up | 4 years |
Countries
Germany
Outcome results
None listed