Pneumonia
Conditions
Keywords
pneumonia, diagnosis, prognosis, tracheal aspirate, bronchoalveolar lavage
Brief summary
The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia. In presence of bacterial growth on lung samples, the measure of autofluorescence of white corpuscles could help the clinicians to discriminate bacterial colonization from acute infection.
Interventions
OTHERAutofluorescence of white corpuscle
Measure of auto-fluorescence of white corpuscles cells harvested from tracheal aspirate and/or bronchoalveolar lavages
Sponsors
Nantes University Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Hospitalization in intensive care units * Mechanical ventilation * Age \> 18 years * Collection of a lung sample for bacteriological analysis for the suspicion of a first episode of lung infection.
Exclusion criteria
* Refuse to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pneumonia | 28 days | Diagnosis of pneumonia (Clinical Pulmonary Infection Score \> 6, with assessment of the chest radiography by a blinded investigator) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Pulmonary Infection Score > 6 | day 3 | — |
| Acute respiratory distress syndrome | day 90 | PaO2/FiO2 \< 200 with a PEEP \> 5 (Berlin definition) |
| Duration of mechanical ventilation | day 90 | — |
| Intensive Care unit Length of stay | day 90 | — |
| Mortality | day 90 | — |
Countries
France
Outcome results
None listed