Solid Tumor, Adult
Conditions
Brief summary
In the current study, the investigators plan to expand the knowledge of Positron Emission Tomography/Magnetic Resonance (PET/MR) reliability by assessing the repeatability of fludeoxyglucose (FDG) standardized uptake values (SUV) measurements, as well as apparent diffusion coefficients (ADC) measurements, in a broad population of patients with malignant solid tumors.
Interventions
RADIATIONFludeoxyglucose F 18
DEVICEPositron Emission Tomography
DEVICEComputerized Tomography
DEVICEMagnetic Resonance Imaging
Sponsors
Washington University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with histologically confirmed malignant solid tumors (local or metastatic, newly diagnosed or recurrent disease). * Patient must have at least one lesion measuring ≥ 2.0 cm. * 18 years of age or older. * Ability to provide informed consent.
Exclusion criteria
* Cancer therapy within 30 days of baseline imaging. * Uncontrolled intercurrent illness including, but not limited to active infections. * Patients with insulin-dependent diabetes. * Patients with metal devices in the body including, but not limited to metallic joint prostheses, artificial heart valves, pacemakers, and cochlear implants. * Patients who are pregnant or nursing. * Inability to tolerate 60 minutes of PET imaging. * Inability to comply with study procedures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variability of repeated quantitative measures of FDG uptake as measured by SUVmax | Completion of study (up to Day 7) | -SUVmax is the maximum standardized uptake value (SUV) of the area of showing metabolic activity and this is used to show response |
| Variability of repeated quantitative measures of FDG uptake as measured by SUVpeak | Completion of study (up to Day 7) | -SUVpeak, which is defined as the average SUV within a 1 cubic cm volume within the region of the tumor with the highest metabolic activity |
| Repeatability of diffusion-weighted imaging on PET/MR as measured by difference in mean ADC | Completion of study (up to Day 7) | * DW MRI is a method of mapping the diffusion process of water within and between tissues * Water diffusion is described quantitatively by apparent diffusion coefficients (ADC) |
| Repeatability of diffusion-weighted imaging on PET/MR as measured by differences in minimum ADC | Completion of study (up to Day 7) | * DW MRI is a method of mapping the diffusion process of water within and between tissues * Water diffusion is described quantitatively by apparent diffusion coefficients (ADC) |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the ratio of SUVmax and ADCmin | Completion of study (up to Day 7) |
Countries
United States
Outcome results
None listed