Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02717559

Enrollment

225

Registered

2016-03-23

Start date

2016-03-01

Completion date

2025-12-01

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthritis, Joint Diseases, Musculoskeletal Diseases, Osteoarthritis, Rheumatic Diseases

Keywords

Anterior cruciate ligament / injuries, Anterior cruciate ligament / surgery, knee injuries / surgery, outcomes research, prospective studies, osteoarthritis

Brief summary

In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

Detailed description

The purpose of this study is to identify risk factors for signs and symptoms of osteoarthritis two and ten year post ACL reconstruction from information available at the time of surgery. Hypothesis: Smoking status, older age, higher BMI, increased severity of cartilage injuries, increased meniscal resection, revision surgery, and incidence of additional arthroscopic procedures will result in more symptoms and signs of osteoarthritis at 10-year follow-up. Primary outcome measures will be the joint space width measured on weight-bearing radiographs, as well as the pain subscale of the Knee Injury and Osteoarthritis Score (KOOS). Secondary outcome measures will include the knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Had primary unilateral ACL reconstruction performed by Dr. Kurt Spindler (Vanderbilt University), Dr. Christopher Kaeding (The Ohio State University), Dr. Rick Parker (Cleveland Clinic), Dr. Jack Andrish (Cleveland Clinic), Dr. Rick Wright (Washington University, St. Louis), or Dr. Matthew Matava (Washington University, St. Louis). * Participated in the 2 yr onsite visit

Exclusion criteria

* Unable to be consented * Unable to participate for health reasons * History of intra-articular knee infection * History of total knee arthroplasty on either knee

Design outcomes

Primary

Measure	Time frame
Joint space width measured on weight-bearing radiographs	10 years after ACL reconstruction surgery
Pain subscale of the Knee Injury and Osteoarthritis Score (KOOS).	10 years after ACL reconstruction surgery

Secondary

Measure	Time frame
Knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS)	10 years after ACL reconstruction surgery

Contacts

PRINCIPAL_INVESTIGATORKurt P Spindler, MD

Vanderbilt University / The Cleveland Clinic Foundation

Outcome results