Overweight, Obesity and Other Hyperalimentation (E65-E68)
Conditions
Keywords
tRNS, Food addiction,, Obesity, Craving, functional magnetic resonance imaging (fMRI)
Brief summary
Obesity is worldwide a public health problem. According to World Health Organization (WHO), overweight and obesity are the fifth death risk factor worldwide. At least 2.8 million adults die each year. Food addiction is one of the causes of obesity that may benefit from new therapeutic options.
Detailed description
Transcranial random noise stimulation is a noninvasive brain stimulation technic. The modulation of the electrical activity of the right and left dorsolateral prefrontal cortex (DLPFC) by tRNS is able to act on the phenomenon of craving in other addictions. This allows us to make the assumption that tRNS stimulation could constitute a treatment for food addiction especially in obesity.
Interventions
The intervention consists in active tRNS stimulation with cathode above the left dorsolateral prefrontal cortex (DLPFC) which corresponds to the F3 location given by the 10-20 system. Anode is above the right dorsolateral prefrontal cortex (F4). 100Hz-650Hz, 2mA, 30min, twice daily, 5 days
The intervention consists in placebo or sham tRNS stimulation electrode are above F3 and F4. Voltage will be ramped at the begin and end of a stimulation for 30 seconds. Placebo stimulation will consist of just applying the ramps at the begin and end of the stimulation.
Sponsors
Study design
Eligibility
Inclusion criteria
* Female or male between 18 and 65 years old * Patients suffering from obesity, with a BMI ≥ 30. * Food dependence score at the Yale Food addiction Scale ≥ 3
Exclusion criteria
* Presence of a an other psychiatric diagnosis of Axis I (DSM IV); * Presence of addictive comorbidity other than food addiction * Psychotropic treatment; * Pregnancy or lactation; * Contraindication to fMRI .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects on craving frequencies | Change from baseline after 3 months | by questionnaires scores and declarative number of food |
Secondary
| Measure | Time frame |
|---|---|
| change in body weight | Change from baseline after 3 months |
| change in waist circumference | Change from baseline after 3 months |
| change in body mass index | Change from baseline after 3 months |
| change in biological markers such as lipid profile, ghrelin, leptin, prolactin | Change from baseline after 3 months |
Countries
France