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Transcranial Random Noise Stimulation in Food Addiction Treatment

Effect of Transcranial Random Noise Stimulation of Prefrontal Cortex on Craving Supply Subject Suffering From Obesity

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02717247
Acronym
tRNS-FA
Enrollment
13
Registered
2016-03-23
Start date
2016-02-29
Completion date
2019-05-02
Last updated
2020-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight, Obesity and Other Hyperalimentation (E65-E68)

Keywords

tRNS, Food addiction,, Obesity, Craving, functional magnetic resonance imaging (fMRI)

Brief summary

Obesity is worldwide a public health problem. According to World Health Organization (WHO), overweight and obesity are the fifth death risk factor worldwide. At least 2.8 million adults die each year. Food addiction is one of the causes of obesity that may benefit from new therapeutic options.

Detailed description

Transcranial random noise stimulation is a noninvasive brain stimulation technic. The modulation of the electrical activity of the right and left dorsolateral prefrontal cortex (DLPFC) by tRNS is able to act on the phenomenon of craving in other addictions. This allows us to make the assumption that tRNS stimulation could constitute a treatment for food addiction especially in obesity.

Interventions

The intervention consists in active tRNS stimulation with cathode above the left dorsolateral prefrontal cortex (DLPFC) which corresponds to the F3 location given by the 10-20 system. Anode is above the right dorsolateral prefrontal cortex (F4). 100Hz-650Hz, 2mA, 30min, twice daily, 5 days

DEVICESham tRNS

The intervention consists in placebo or sham tRNS stimulation electrode are above F3 and F4. Voltage will be ramped at the begin and end of a stimulation for 30 seconds. Placebo stimulation will consist of just applying the ramps at the begin and end of the stimulation.

Sponsors

Hôpital le Vinatier
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Female or male between 18 and 65 years old * Patients suffering from obesity, with a BMI ≥ 30. * Food dependence score at the Yale Food addiction Scale ≥ 3

Exclusion criteria

* Presence of a an other psychiatric diagnosis of Axis I (DSM IV); * Presence of addictive comorbidity other than food addiction * Psychotropic treatment; * Pregnancy or lactation; * Contraindication to fMRI .

Design outcomes

Primary

MeasureTime frameDescription
Effects on craving frequenciesChange from baseline after 3 monthsby questionnaires scores and declarative number of food

Secondary

MeasureTime frame
change in body weightChange from baseline after 3 months
change in waist circumferenceChange from baseline after 3 months
change in body mass indexChange from baseline after 3 months
change in biological markers such as lipid profile, ghrelin, leptin, prolactinChange from baseline after 3 months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026