Keratitis of Both Eyes
Conditions
Keywords
keratitis, AMT, bacterial keratitis, medication
Brief summary
In this study Investigators are going to do early amniotic membrane transplantation (AMT) for bacterial keratitis.
Detailed description
In this study investigators are going to do amniotic membrane transplantation (AMT), early in the first week for bacterial keratitis. Investigators are comparing this technique with no amniotic membrane transplantation (NAMT) in a clinical trial, Inform consent is going to be taken, then the enrolment population is added in the study. Investigators are going to compare the final scar size, the time to scar formation, perforation rate , early need to penetrating keratoplasty (PKP), risk of vision loss (being no light perception (NLP) between two groups.This trial has been approved by the review board in Tehran University of Medical Sciences.( 487/5671)
Interventions
PROCEDUREAMT
The AM was trimmed in two layers to fit the corneal ulcer and was placed with its epithelium (basement membrane) side up, secured with 10/0 nylon sutures, supported by a therapeutic contact lens. The operated eye was patched for 2 h, and then administration of the medical treatment agents was resumed. In patients in the case group AMT was performed during days 2-5 of antibiotic therapy when initial clinical response to the treatment was observed.
Sponsors
Farabi Eye Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Bacterial keratitis being in the first week of diagnosis medically undergoing treatment
Exclusion criteria
thinning limbal extension intraocular extension underlying disease Nocardia keratitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to scar formation | It needs at most 3 months | The time keratitis needs for scar to be formed |
Outcome results
None listed