Bleeding During Myomectomy
Conditions
Brief summary
the aim of the study is To compare the effectiveness of rectally administered prostaglandin E1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before myomectomy to decrease blood loss during and after the operation.
Interventions
patients will take 2 tablets of rectally misoprostol 400 microgram 60 minutes before the procedure
patients will take 2 tablets of sublingual misoprostol 400 microgram 60 minutes before the procedure
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting for abdominal myomectomy with documented uterine fibroids on pelvic imaging * Age ≥ 18 years and ≤ 50 years * Pre-operative hemoglobin \>8 g/dl * Ability to understand and the willingness to sign a written informed consent. * Admissible medical/surgical history * Five or less symptomatic uterine myomas * All myomas are subserous or intramural. * Uterine size less than 24 weeks pregnancy
Exclusion criteria
* Patients who have had a prior abdominal myomectomy * Post-menopausal women * Patients with known bleeding/clotting disorders * Patients with a history of gynecologic malignancy * Hypertension. * Cardiac and Pulmonary diseases. * Obesity (body mass index \> 30 kg/m2). * History of allergic reactions attributed to misoprostol * Cases that will require intraoperative conversion of myomectomy to hysterectomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean amount of blood loss | intraoperative |
Secondary
| Measure | Time frame |
|---|---|
| Change of hemoglobin level | 24 hours |
Countries
Egypt
Outcome results
None listed