Carcinoma, Non-Small-Cell Lung
Conditions
Keywords
Drug Therapy
Brief summary
This study is about a medicine called TAK-788, also known as mobocertinib, given to adults with non-small cell lung cancer. The main aims of this study are to check if there are any side effects from TAK-788, to learn how TAK-788 is processed by the body, and to determine the best dose of TAK-788 to treat this condition. Participants will take TAK-788 capsules with chemotherapy. Participants will continue to take TAK-788 unless they or their doctor decide they should stop this treatment. Participants will take TAK-788 capsules with or without chemotherapy under antidiarrhea prevention to determine the safety of TAK-788 treatment. Non-Asian, non-White participants will take TAK-788 to determine the safety and tolerability of TAK-788 treatment.
Detailed description
This phase 1/2 study will evaluate the safety, pharmacokinetics, and anti-tumor activity of oral EGFR/HER2 Inhibitor TAK-788 in participants with NSCLC and anti-tumor activity of TAK-788 in participants with solid tumors other than NSCLC with EGFR or HER2 mutations. The trial will be conducted in three parts: a dose escalation (Part 1), expansion phase (Part 2), followed by an extension phase (Part 3). The objectives of the dose escalation phase (Part 1), is to determine the safety profile of orally administered TAK-788, including the MTD, DLTs, RP2D, pharmacokinetic profile. The primary goal of the expansion component of the trial is to evaluate the anti-tumor activity of TAK-788 in seven histologically and molecularly defined cohorts at the RP2D (determined based on dose escalation phase of the trial). The seven expansion cohorts will be: 1. NSCLC participants with EGFR exon 20 activating insertions, who have either not received or not shown an objective response to an EGFR TKI, and who have no active, measurable CNS metastases; 2. NSCLC participants with HER2 exon 20 activating insertions or point mutations and no active, measurable CNS metastases; 3. NSCLC participants with EGFR exon 20 activating insertions or HER2 exon 20 activating insertions or point mutations and active, measurable CNS metastases; 4. NSCLC participants with other targets against which TAK-788 is active (examples include EGFR exon 19 deletions or exon 21 substitutions \[with or without T790M mutations\] and other uncommon EGFR activating mutations), without active CNS metastases; 5. NSCLC participants with EGFR exon 20 activating insertions, who have previously shown an objective response to an EGFR TKI and subsequently progressed, without active CNS metastases; 6. NSCLC participants with EGFR exon 20 activating insertions, who have not received prior systemic anticancer treatment for locally advanced or metastatic disease, without active CNS metastases; and 7. Participants with solid tumors other than NSCLC with EGFR/HER2 mutations against which TAK-788 is active, without active CNS metastases. The extension phase will evaluate efficacy of TAK-788 in participants with locally advanced or metastatic NSCLC whose tumors harbor EGFR exon 20 insertion mutations and who have been previously treated. The study enrolled 324 participants.
Interventions
DRUGTAK-788
TAK-788 capsules.
Sponsors
Takeda
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
General Inclusion Criteria all cohorts: dose escalation, antidiarrhea prophylaxis, dose escalation combination, expansion, and extension: 1. Have histologically or cytologically confirmed locally advanced (and not a candidate for definitive therapy) or metastatic NSCLC disease (Stage IIIB or IV) or other solid tumors. For all cohorts except Expansion Cohort 7, the locally advanced or metastatic disease is NSCLC. For Expansion Cohort 7, the locally advanced or metastatic disease is any solid tumor other than NSCLC. 2. Must have sufficient tumor tissue available for analysis. 3. Must have measurable disease by response evaluation criteria in solid tumors (RECIST) v1.1. 4. Male or female adult participants (aged 18 years or older, or as defined per local regulations). 5. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1. 6. Minimum life expectancy of 3 months or more. 7. Adequate organ function at baseline. 8. Normal QT interval on screening electrocardiogram (ECG), defined as QT interval corrected (Fridericia) (QTcF) of less than or equal to (≤ ) 450 millisecond (ms) in males or ≤ 470 ms in females. 9. Willingness and ability to comply with scheduled visits and study procedures. Part 1: Dose Escalation Cohort Specific Inclusion Criteria: 1\. Refractory to standard available therapies. Part 2: Expansion Cohort 1 Specific Inclusion Criteria: 1. Have a documented EGFR in-frame exon 20 insertion by a local test. 2. Previously treated with one or more regimens of systemic therapy for locally advanced or metastatic disease. 3. Prior treatment with an EGFR TKI is allowed unless the participants had an objective response and subsequent progression as assessed by the investigator or treating physician. Expansion Cohort 2 Specific Inclusion Criteria: 1. Have one of the following documented by a local test: 1. A HER2 exon 20 insertion; 2. An activating point mutation in HER2. 2. Previously treated with one or more regimens of systemic therapy for locally advanced or metastatic disease. 3. With an EGFR exon 20 insertion: Prior treatment with a pan-HER TKI (example, afatinib, neratinib, or dacomitinib) is allowed unless the participants had an objective response and subsequent progression as assessed by the investigator or treating physician. Part 2: Expansion Cohort 3 Specific Inclusion Criteria: 1. Have one of the following documented by a local test: 1. An EGFR exon 20 insertion; 2. A HER2 exon 20 insertion; 3. An activating point mutation in HER2. 2. Previously treated with one or more regimen of systemic therapy for locally advanced or metastatic disease. 3. For participants with an EGFR exon 20 insertion: prior treatment with an EGFR TKI is allowed unless the participants had an objective response and subsequent progression as assessed by the investigator or treating physician. 4. For participants with a HER2 exon 20 insertion or HER2 activating point mutation: prior treatment with a pan-HER TKI (example, afatinib, neratinib, or dacomitinib) is allowed unless the participants had an objective response and subsequent progression as assessed by the investigator or treating physician during treatment with that prior TKI. 5. Have either previously untreated intracranial CNS metastases or previously treated intracranial CNS metastases with radiologically documented new or progressing CNS lesions. 6. Have at least one target (that is, measurable) intracranial CNS lesion (greater than or equal to \[ ≥ \]10 millimeter \[mm\] in longest diameter by contrast enhanced magnetic resonance imaging \[MRI\]). Part 2: Expansion Cohort 4 Specific Inclusion Criteria: 1. Have one of the following documented by a local test: an activating mutation in EGFR including exon 19 deletions or exon 21 L858R substitution (with or without T790M), or an uncommon activating mutation other than exon 20 insertion including, but not limited to, G719X (where X is any other amino acid), S768I, L861Q, or L861R. 2. Treatment naive for locally advanced or metastatic disease or previously treated with one or more regimens of systemic therapy for locally advanced or metastatic disease. Part 2: Expansion Cohort 5 Specific Inclusion Criteria: NSCLC participants with EGFR exon 20 activating insertions, who have previously shown an objective response to an EGFR TKI and subsequently progressed, without active CNS metastases. 1. Have a documented EGFR in-frame exon 20 insertion by a local test. 2. Previously treated with one or more regimens of systemic therapy for locally advanced or metastatic disease. 3. Previously showed an objective response to an EGFR TKI, and subsequently progressed as assessed by the investigator or treating physician. Part 2: Expansion Cohort 6 Specific Inclusion Criteria: NSCLC participants with EGFR exon 20 activating insertions, who have not received prior systemic anticancer treatment for locally advanced or metastatic disease, without active CNS metastases. 1. Have a documented EGFR in-frame exon 20 insertion by a local test. 2. No prior systemic treatment for locally advanced or metastatic disease. Part 2: Expansion Cohort 7 Specific Inclusion Criteria: Participants with solid tumors other than NSCLC with EGFR/HER2 mutations against which TAK-788 is active, without active CNS metastases. 1. Have a solid tumor that is not NSCLC, including, but not limited to, bladder/urinary tract cancer, breast cancer, gastric/esophageal cancer, biliary tract cancer, and head and neck cancer. 2. Is refractory to standard therapy. 3. Have EGFR or HER2 mutations, documented by a local test. Part 3: Extension Cohort Specific Inclusion Criteria: 1. Have a documented EGFR in-frame exon 20 insertion by a local test and sufficient tumor tissue available for central analysis. 2. Must have received at least 1 prior line of therapy for locally advanced or metastatic disease and no more than 2 regimens of systemic anticancer chemotherapies for locally advanced or metastatic disease. * Prior treatment with an EGFR TKI is allowed unless the participant had an objective response and subsequent progression as assessed by the investigator or treating physician during treatment with that prior TKI.
Exclusion criteria
1. Previously received TAK-788. 2. Received small-molecule anticancer therapy (including cytotoxic chemotherapy, and investigational agents, ≤ 14 days prior to first dose of TAK-788 (except for reversible EGFR TKIs \[that is, erlotinib or gefitinib\], which are allowed in the dose escalation and expansion cohorts up to 7 days prior to the first dose of TAK-788). 3. Received antineoplastic monoclonal antibodies including immunotherapy within 28 days of the first dose of TAK-788. 4. Have been diagnosed with another primary malignancy other than NSCLC except for adequately treated non-melanoma skin cancer or cervical cancer in situ; definitively treated non-metastatic prostate cancer; or participants with another primary malignancy who are definitively relapse-free with at least 3 years elapsed since the diagnosis of the other primary malignancy. Note: This
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 2, Expansion Cohort 3: Intracranial ORR (iORR) Assessed by Independent Review Committee (IRC) | Up to 36 months after first dose |
| Part 2, Expansion Cohort 6: Confirmed ORR Assessed by IRC | Up to 36 months after first dose |
| Part 3, Extension Cohort: Confirmed ORR Assessed by IRC | Up to 36 months after first dose |
| Part 1, Dose Escalation Component: Recommended Phase 2 Dose (RP2D) of Orally Administered TAK-788 | Cycle 1 (Cycle length is equal to [=] 28 days) |
| Part 2, Expansion Cohorts 1, 2, 4, 5 and 7: Confirmed Objective Response Rate (ORR) Assessed by the Investigator | Up to 36 months after first dose |
Secondary
| Measure | Time frame |
|---|---|
| Part 1, Dose Escalation Component: Dose Limiting Toxicities (DLTs) of TAK-788 | Cycle 1 (Cycle length=28 days) |
| Part 1, Dose Escalation Component: Maximum Tolerated Dose (MTD) of TAK-788 | Cycle 1 (Cycle length=28 days) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: Cmax; Maximum Observed Concentration of TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: Tmax; Time of First Occurrence of Maximum Plasma Concentration (Cmax) of TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: AUC 24; Area Under the Concentration-time Curve from Time Zero to 24 hours for TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: AUCt: Area Under the Concentration-time Curve from Time Zero to Time t for TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: RAC (Cmax): Accumulation Ratio Based on Cmax of TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Parts 1 and 2, Dose Escalation and Expansion Cohorts: RAC (AUC): Accumulation Ratio Based on AUC of TAK-788 and its Metabolites | Cycle 1 Day 1 and Cycle 2 Day 1 (cycle length=28 days for Parts 1 and 2) |
| Part 2, Expansion Cohorts 1, 2, 3, 4, 5, and 7: Confirmed ORR as Assessed by IRC | Up to 36 months after first dose |
| Part 2, Expansion Cohorts: Best Overall Response as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Part 2, Expansion Cohorts: Best Target Lesion Response as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Parts 2 and 3, Expansion and Extension Cohorts: Duration of Response as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Parts 2 and 3, Expansion and Extension Cohorts: Disease Control Rate (DCR) as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Part 2 and 3, Expansion and Extension Cohorts: Time to Response as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Parts 2 and 3, Expansion and Extension Cohorts: Progression Free Survival (PFS) as Assessed by the Investigator and IRC | Up to 36 months after first dose |
| Part 3, Number of Participants With Patient-reported Symptoms (Lung Cancer), Functioning, and Health-related Quality of Life (HRQoL) Based on European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-core 30 (EORTC QLQ-C30) | Up to 30 days after last dose of drug (approximately up to 37 months) |
| Parts 2 and 3, Expansion and Extension Cohorts: Overall Survival (OS) | Up to 36 months after first dose |
| Part 3, Extension Cohort: Number of Participants With Patient-reported Symptoms (Lung Cancer), Functioning, and health-related Global Quality of Life (HRQoL) Based on Quality of Life Questionnaire Lung Cancer Module-13 (QLQ-LC13) | Up to 30 days after last dose of drug (approximately up to 37 months) |
| Part 2, Expansion Cohort 3: Duration of Intracranial Response (iDOR) | up to 36 months after first dose |
| Part 2, Expansion Cohort 3: Intracranial PFS (iPFS) | up to 36 months after first dose |
| Part 2, Expansion Cohorts 6: Confirmed ORR as Assessed by the Investigator | Up to 36 months after first dose |
| Part 3, Extension Cohort: Confirmed ORR as Assessed by the Investigator | Up to 36 months after first dose |
Countries
China, Germany, Italy, Japan, Puerto Rico, South Korea, Spain, Taiwan, United Kingdom, United States
Contacts
STUDY_DIRECTORStudy Director
Takeda
Outcome results
None listed