Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02715869

Enrollment

100

Registered

2016-03-22

Start date

2016-03-31

Completion date

2017-06-30

Last updated

2017-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Ischemia

Keywords

Myocardial Preconditioning, inotropic score

Brief summary

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be (ischemic ; pharmacologic or Physical).

Detailed description

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ; pharmacologic or Physical) Pharmacological PC may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc) Ischemic PC includes local; remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs. The liberated mediators have favorable effects not only upon the myocardium, but it extend to protect other organs against inflammatory activation; ischemia reperfusion injury Inotropic score (IS) is already an evident predictor of postoperative cardiac morbidity and mortality Aim of the work: Is to validate the impact of Sevoflurane versus ischemic & Sevoflurane PC upon postoperative inotropic score in adult patient undergoing open heart surgery

Interventions

DRUGA pharmacologic cardiac preconditioning (Sevoflurane)

A Patients are anaesthetized by Sevoflurane more than 1 mac.

PROCEDUREB ischeamic preconditioning

B ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* 18-60 years old * American Society of Anesthesiologists physical status II and III * Patients scheduled for open heart surgery

Exclusion criteria

* Emergency surgery * Clinically significant kidney or liver disease * Patients allergic to local anesthetic * Patients with prolonged cardiopulmonary bypass time (\>120 min) * Patients required intra-aortic balloon pump * Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Design outcomes

Primary

Measure	Time frame
Highest inotropic score	first 24 hour

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026