Acute Tonsillitis, Infectious Mononucleosis, Peritonsillar Cellulitis
Conditions
Keywords
fusobacterium necrophorum, acute tonsillitis, peritonsillar cellulitis, infectious mononucleosis, microbiology, antibody development
Brief summary
Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.
Detailed description
Patients referred to tertiary care centers with acute throat infections are most often treated with antibiotics. However, very little is know concerning the prevalent pathogens in patients with acute throat infections without abscess formation. Evidence suggests that Fusobacterium necrophorum plays an important role in complications of acute tonsillitis (e.g. peritonsillar abscess), but also uncomplicated acute tonsillitis. This study aims to explore the throat microbiology of patients with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis with a special attention to a possible role of Fusobacterium necrophorum.
Interventions
OTHERThroat swabbing
Sponsors
Statens Serum Institut
Tejs Ehlers Klug
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients referred to our tertiary care center with acute tonsillitis with or without signs of peritonsillar cellulitis and with or without infectious mononucleosis. 2. Center Score 3 or 4.
Exclusion criteria
1. Abscess formation. 2. Previous tonsillectomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of Fusobacterium necrophorum in throat swab cultures | At acute consultation (day 0) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with recurrent throat infections (questionnaire) | Six months after acute consultation | — |
| Number of participants without eradication of throat pathogens (throat cultures) | 14-28 days after acute consultation | Throat pathogens: Fusobacterium necrophorum, Beta-hemolytical streptococci, A. hemolyticum |
| Number of participants with complications of severe acute tonsillitis, peritonsillar cellulitis, and infectious mononucleosis | 14-28 days after acute consultation | Complications: admission, abscess Development, change of antibiotic treatment |
| Prevalence of anti-Fusobacterium necrophorum antibody Development (two-fold or higher increase in antibody level) (blood samples) | In acute and convalescent sera (day 0 and 14-28) | Comparison of the prevalence of antibody Development (two-fold or higher increase in antibody level) between patients with recovery of Fusobacterium necrophorum in throat swabs versus patients without recovery of Fusobacterium necrophorum in throat swabs |
Countries
Denmark
Outcome results
None listed