Ectopic Pregnancy, Infertility
Conditions
Keywords
ectopic pregnancy, ovarian reserve, salpingectomy, methotrexate
Brief summary
The investigators aimed to investigate the effects of salpingectomy and Methotrexate administration on ovarian reserve in ectopic pregnancy.
Detailed description
In this study, the effects of unilateral laparoscopic salpingectomy and single dose of systemic Methotrexate administration on ovarian reserve in patients diagnosed with ectopic pregnancy were investigated.
Interventions
DRUGMethotrexate
single dose systemic methotrexate administration (50 mg/m2)
PROCEDUREsalpingectomy
Laparoscopic unilateral salpingectomy
Sponsors
Ege University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ectopic pregnancy diagnosis
Exclusion criteria
* history of endometriosis, ovarian surgery, systemic chemotherapy, ART treatment. * patients treated with multiple doses of methotrexate or different surgical procedure (salpingostomy, milking)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ovarian reserve assessment by measuring AMH level. | 1-3 months | Ovarian reserve were assessed before and after treatment by measuring AMH levels. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with treatment related adverse effect on fertility. | 2 years of follow up after treatment | Rates of term delivery, spontaneous abortion, recurrent ectopic pregnancy and ongoing pregnancy for each group of patients were calculated during 2 years of follow up period. |
Countries
Turkey (Türkiye)
Outcome results
None listed