Sensitive Troponin I in Out-of-hospital Cardiac Arrest

Sensitive Troponin I and Coronary Anatomy in Patients With Out-of-hospital Cardiac Arrest

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02713048

Enrollment

159

Registered

2016-03-18

Start date

2011-10-31

Completion date

2018-10-31

Last updated

2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Lesion, Cardiac Arrest, Non-obstructive Coronary Disease, Stable Obstructive Coronary Disease

Keywords

Cardiac arrest, Troponin I, coronary anatomy

Brief summary

Troponin is a major diagnostic criterion of acute myocardial infarction (AMI) which confirms myocardial damage and necrosis. In out-of-hospital cardiac arrest (OHCA) patients its dynamics and diagnostic value is often controversial and has not been well described. Most of prior studies were retrospective, using first generation troponin assays and assessing only admission troponin. The aim of this work is to correlate dynamics of sensitive troponin I with urgent coronary angiography. Patients resuscitated after OHCA will be prospectively divided in three groups based on the results of their urgent angiographies. Serial assessment of sensitive troponin I will be obtained over initial 48 hours. We expect admission troponin will not be predictive of AMI. Over next hours troponin levels will be highest in patients with acute coronary lesion, lower in stable obstructive coronary disease and insignificant in non-obstructive coronary disease. We also expect significant difference in highest values and dynamics of troponin in sub-group with spontaneous reperfusion (TIMI flow 2 and 3) comparing to patients with coronary occlusion (TIMI flow 0 and 1). In patients with non-obstructive disease we expect troponin levels to correlate with duration of cardiac arrest, number of external electric shocks and cumulative dose of adrenaline administered.

Interventions

OTHERBlood sample collection

Eight blood samples in each patient within 48 hours to perform Troponin I measurement.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* female and male over 18 years old * comatose survivors after out-of-hospital cardiac arrest (OHCA) * absence of an obvious non-coronary cause * urgent coronary angiography at admittance * less than 3 hours from OHCA to first troponin assessment at admittance

Exclusion criteria

* sub-acute myocardial infarction * coronary spasms or in-stent thrombosis within first 48 hours after admission * Coronary surgery or death within first 48 hours after admission

Design outcomes

Primary

Measure	Time frame	Description
Peak Troponin I value	Within 48 hours after hospital admission	Peak troponin I values will be compared among 3 groups with different coronary anatomy

Secondary

Measure	Time frame	Description
Admission troponin I value	Within 3 hours of cardiac arrest	Admission troponin I will be compared among 3 groups with different coronary anatomy
Peak troponin I value in acute coronary syndrome group	Within 48 hours after hospital admission	Peak troponin I values will be compared among group with coronary artery occlusion and group with spontaneous reperfusion

Countries

Slovenia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026