Breast Cancer, Prostate Cancer, Body Composition, White Adipose Tissue Inflammation
Conditions
Keywords
DEXA Scan, 15-235
Brief summary
The investigators want to find a better way to predict the risk of having fatty tissue inflammation by using a different approach to finding out body fat composition. In this study, the investigators want to estimate the body fat composition using a DEXA scan. DEXA stands for dual energy X-ray absorptiometry. It is the standard and established test to determine bone mineral density (how strong the bones are) to diagnose osteoporosis. This test can also be used to determine the body composition including percent body fat and lean mass. The investigators will compare the participants DEXA scan results for body fat composition to the inflammation found in the breast tissue from the mastectomy to see if there is a relationship. If successful, this may help us predict which patients may be at risk for breast cancer in the future. In addition, the investigators will compare the participants DEXA scan results for body fat composition and inflammation found in the fat tissue from the mastectomy or prostatectomy to the level of exercise activity as measured by a short questionnaire to see if there is a relationship. The investigators will also measure the participants waist to hip ratio. Finally, at the time the participant has blood drawn for their standard presurgical testing, the investigators will also test the blood for prediabetes using a blood test called hemoglocin A1c. The investigators will also measure for the participants waist to hip ratio, and a Hgb A1c blood drawn will be take at the time of presurgical testing. If not feasible, Hgb A1c can be drawn at a separate visit prior to the DEXA scan. If successful, this may help us predict which patients may be at risk for breast cancer in the future.
Interventions
DEVICEDEXA Scan
BEHAVIORALGodin Leisure Time Exercise Questionnaire (GLTEQ)
Sponsors
Weill Medical College of Cornell University
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 * Female * All BMIs * Patients undergoing mastectomy at MSKCC (i.e. Nipple-sparing mastectomy, skin-sparing mastectomy, simple mastectomy, modified radical mastectomy, radical mastectomy); mastectomy may be either prophylactic or therapeutic. OR * Patients undergoing hysterectomy at MSKCC * History of prior breast surgeries/procedures is acceptable
Exclusion criteria
* Pregnancy (confirmed or suspected); * Inability to lay supine on equipment table and maintain the position for the necessary time; * Weight superior to the maximum allowed by the DEXA machine (over 350 lbs or 158 kg); * Greater than 10% baseline weight loss in the past year; * Planned surgical procedure is not a Mastectomy (i.e. breast conservation surgery or other non-mastectomy procedure; such as lumpectomy) or hysterectomy * Metastatic cancer * History of Wasting Syndromes or Cachexia * Use of daily NSAIDs, aspirin, or steroids (other than inhaled or topical) within 30 days of surgery * Use of neoadjuvant systemic or radiation therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fat percentage | 1 year | as measured by DEXA |
| presence of White Adipose Tissue Inflammation (WATi ) | 1 year | as measured by DEXA |
Countries
United States
Outcome results
None listed