Role of K+ and Ca2+ in Development of Muscle Fatigue

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02712658

Enrollment

Registered

2016-03-18

Start date

2015-09-30

Completion date

2016-03-31

Last updated

2017-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skeletal Muscle Fatigue in Humans

Brief summary

The aim of the study is to investigate the role of K+ and Ca2+ in development of muscle fatigue in trained young men.

Interventions

DRUGTerbutaline

K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* physical active healthy men * aged 18-40 years

Exclusion criteria

* smokers * allergy towards terbutaline * chronic disease

Design outcomes

Primary

Measure	Time frame
Change in time to fatigue during knee-extensor exercise	1 day

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026