Pulmonary Hypertension
Conditions
Keywords
pulmonary hypertension, peripheral muscle electrostimulation, capacity of the exercises, quality of life
Brief summary
Pulmonary hypertension (PH) features symptoms related to a decreased cardiac autonomic response, pulmonary function and exercise capacity. Non-pharmacological interventions are low cost and can significant enhance outcomes in these patients. Neuromuscular electrical stimulation (NMES) has been proposed as a viable therapeutic approach in patients with functional limitations, particularly those that present with difficulty to perform exercise protocols. Objective: to evaluate the impact of NMES on exercise capacity, spirometry values and quality of life of patients with PH. Material and methods: prospective randomized controlled study with a control group (GC, n9) and NMES goup (GE, n8). Quality of life and exercise capacity through the six-minute walk test (6MWT) were assessed before and after the NMES protocol. Results: the GE presented with a significant improvement in distance walked in the 6MWT, cycle ergometry, spirometry and quality of life in the areas of vitality, emotional and social aspects of the questionnaire Short Form Health Survey-36. Conclusion: NMES is a useful tool in the treatment of patients with PH, resulting in improved exercise capacity, quality of life and lung function testing.
Interventions
OTHERNeuromuscular Electrical Stimulation
Sponsors
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Males and females greater than or equal to 18 years of age, clinically stable with optimized drug therapy in the last 3 months, previously diagnosed with a mean pulmonary arterial pressure ≥ 25 mmHg by right heart catheterization and who agreed to participate by signing an informed consent were included.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Borg scale in six-minute walk test | change from baseline in Borg scale at 2 months | analysis of Borg scale at end of test |
| Distance in six-minute walk test | change from baseline in distance at 2 months | analysis of distance |
| Oxygen saturation in six-minute walk test | change from baseline in oxygen saturation at 2 months | analysis of oxygen saturation at end of test |
| Systolic blood pressure in six-minute walk test | change from baseline in systolic blood pressure at 2 months | analysis of systolic blood pressure at end of test |
| Diastolic blood pressure in six-minute walk test | change from baseline in diastolic blood pressure at 2 months | analysis of diastolic blood pressure at end of test |
| Heart rate in six-minute walk test | change from baseline in heart rate at 2 months | analysis of heart rate at end of test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Forced vital capacity | change from baseline at 2 months | spirometric analysis |
| Forced expiratory volume in the first second | change from baseline at 2 months | spirometric analysis |
| Forced expiratory flow 25-75 % | change from baseline at 2 months | spirometric analysis |
| Ratio of forced expiratory volume in the first second and forced vital capacity | change from baseline at 2 months | spirometric analysis |
| The Medical Outcomes Study 36-item Short Form Health Survey | change from baseline at 2 months | The questionnaire covers 36 items, designed to assess health concepts |
Countries
Brazil
Outcome results
None listed