Healthy Volunteer, High-frequency Ventilation, Lung Diseases, Non-invasive Ventilation
Conditions
Brief summary
The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.
Detailed description
High frequency ventilation (HF-V) allows to ensure oxygen delivery and carbon dioxide clearance despite the absence of thoracic movement in anesthetized, invasively ventilated subjects. This same technique could be applied by a non-invasive interface (HF-NIV), allowing to obtain a prolonged apnea (absence of thoraco-abdominal respiratory movements) in awaken subjects. Such an application would be of interest for several clinical applications, e.g. lung imaging and radio-therapy treatment on lung cancer. The purpose of the study is to assess the effect of different HF-NIV setting on the apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung diseases.
Interventions
DEVICEHigh-frequency non-invasive ventilation
Comparison of 2 different settings of HF-NIV
Sponsors
Centre Hospitalier Universitaire Vaudois
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* healthy subjets : normal respiratory function and no known lung disease * lung disease patients : chronic obstructive pulmonary disease, Sarcoidosis, Cystic fibrosis * age \>=18y
Exclusion criteria
* increased pneumothorax risk under positive pressure ventilation * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of apnea | 1 study session (2 hours) | Duration of apnea according to the different settings of the HF-NIV, defined as absence of thoraco-abdominal respiratory movements |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Transcutaneous carbon dioxide partial pressure | 1 study session (2 hours) | Evolution of transcutaneous carbon dioxide partial pressure (TcCo2) |
| Oxygen saturation of arterial blood | 1 study session (2 hours) | Evolution of oxygen saturation, measured by pulse-oximetry (SatO2) |
| Lung volume | 1 study session (2 hours) | Evolution of lung volume |
| Subjective tolerance | 1 study session (2 hours) | Subjective tolerance of the HF-NIV (questionnaire) |
Countries
Switzerland
Contacts
Primary ContactAlban Lovis, MD
Backup ContactAdam Ogna, MD
Outcome results
None listed