Injuries, Musculoskeletal Pain
Conditions
Brief summary
This study will explore the contribution of stress-system activity to pain and functional disability in the acute stage of traumatic musculoskeletal injury, and to the maintenance of symptoms after 3, 6 and 12 months post-injury.
Detailed description
Purpose: The purpose of this protocol is to establish a longitudinal database of data collected from people having experienced an acute traumatic injury to their musculoskeletal system. This includes injuries commonly considered 'non-catastrophic' or 'minor' soft tissue injuries such as whiplash, low back injuries, sports or slip and fall-type injuries that result in sprain/strain of muscle, tendon, ligament or other such soft tissues. Uncomplicated bony fractures (those that are managed through casting only, non-surgical) will also comprise this cohort. The data will include biological specimens, psychological and cognitive profiles, and social/environmental indicators. This protocol represents the start of the SYStematic Merging of Biology, Mental health and Environment (SYMBIOME) project from the emerging Solving Traumatic pain and disability through Advanced Research Translation (START) research group centred at Western. Over time, this database will allow rich exploration of complex interactions between biology, psychology and environment as they relate to the resolution of traumatic pain and disability, or similarly the persistence thereof. Additional research ethics board (REB) applications will be submitted as those projects are ready to be formally conducted.
Interventions
OTHERNo intervention
No intervention - observational study
Sponsors
The Canadian Pain Society
Canadian Institutes of Health Research (CIHR)
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Eligible participants: 1. Will be aged 18 years or older 2. Will be able to speak and understand conversational (grade 6) English 3. Will be free of cognitive impairments that would interfere with ability to follow directions (e.g. diagnosed Alzheimer's Dementia, Down's Syndrome) 4. Will be free of neuromuscular disorder that impairs mobility (e.g. stroke, multiple sclerosis, cerebral palsy, ALS) 5. Will be free of active malignancies for the past 5 years 6. Will be free of systemic inflammatory conditions, including rheumatoid or psoriatic arthritis, scleroderma, or systemic lupus erythematosus 7. Will not have been diagnosed with a concussion over the previous 6 months (including the current injury) 8. Will not have been hospitalized overnight over the previous 6 months (including the current injury) 9. Will not have taken steroid-based medications (either prescribed or self-administered) over the previous 6 months 10. Will not have required surgical correction/relocation as a result of the trauma (e.g. open reduction/internal fixation of a fracture). -
Exclusion criteria
* Those who are under the influence of drugs or alcohol, or are otherwise not able to provide appropriate informed consent at the time of contact and those with no fixed address will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recovery change | 1, 2, 3, 6, and 12 months | Change in Satisfaction and Recovery Index |
| Functional Recovery | 1, 2, 3, 6, 12 months | Brief Pain Inventory - Interference Subscale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Work status | 1, 2, 3, 6, and 12 months | Work status in relation to pre-injury status |
| Change in Pain | 1, 2, 3, 6, and 12 months | Numeric Rating Scale |
| Change in Post-traumatic Stress | 1, 2, 3, 6, and 12 months | PTSD Checklist |
| Change in Depressive Symptoms | 1, 2, 3, 6, and 12 months | Patient Health Questionnaire - 9 |
Countries
Canada
Outcome results
None listed