Diabetes, Hypercalcemia, Hyperparathyroidism
Conditions
Keywords
hyperparathyroidism, insulin resistance
Brief summary
The aims of this study is to analyse if insulin resistance in primary hyperparathyroidism (pHPT) is normalised after parathyroid adenomectomy and if glucose tolerance test may be useful as a diagnostic tool by predicting potential improvement of insulin sensitivity after biochemical cure of pHPT.
Detailed description
To be conducted at the Karolinska University Hospital, Stockholm. Patients with fb-glucos \>6.1 and HbA1c without medical treatment will be included after informed consent and randomised to parathyroidectomy (PTX) within three months or not. The groups will be examined 4 ±4 weeks before and 12±2 weeks after PTX, similar for the control group. The number of participants will be estimated by power calculations based on a pilot study including 20 patients. The test protocol includes glucose load with control of glucose and insulin, (0, 30, 60 and 120 min) together with measurement of markers of oxidative stress and inflammation.
Interventions
PROCEDUREparathyroidectomy
surgical treatment of hyperparathyroidism
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* primary hyperparathyroidism and fb-glukos\>6,1 and/or HbA1c \> 39 mmol/mol
Exclusion criteria
* Treatment with insulin, sulfonylurea or metformin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| glucose tolerance test with estimation of insulin resistance | 3 months | Homa IR |
| quality of life - self estimation protocol | 3 months | EORTC QLQ-C30 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| psychological wellbeing | 3 months | POMS |
| anxiety, depression | 6 months | HAD |
| cognition | 6 months | MoCA-Test |
Countries
Sweden
Outcome results
None listed