Low-dose Combination of Three Antihypertensive Drugs

Randomized Comparison of Fixed Low-dose Combination of THREE Antihypertensive Drugs Versus Fixed High-dose Combination of Two Antihypertensive Drugs in Arterial Hypertension (the 3D Trial)

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02710552

Acronym

Enrollment

100

Registered

2016-03-16

Start date

2016-04-30

Completion date

2020-03-31

Last updated

2016-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Hypertension

Keywords

arterial hypertension, antihypertensive drugs

Brief summary

The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arterial hypertension

Detailed description

The aim of the study is to compare the efficacy and safety of commercially available low-dose combination of three antihypertensive drugs versus commercially available fixed high-dose combination of two antihypertensive drugs in arterial hypertension

Interventions

DRUGTripliam (perindopril, indapamide, amlodipine)

Fixed combination of perindopril 5 mg, indapamide 1,25 and amlodipine 5 mg

DRUGReaptan (perindopril, amlodipine)

Fixed combination of perindopril 10 mg and amlodipine 5 mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

Patients with arterial hypertension resistant to monotherapy

Exclusion criteria

None

Design outcomes

Primary

Measure	Time frame	Description
Number of patients who reach target blood pressure	From baseline to the end of the 3-month study period	How many patients have blood pressure within normal limits

Countries

Italy

Contacts

Primary ContactFrancesco Pelliccia, MD

md4151@mclink.it390649971

Backup ContactCesare Greco, MD