Pituitary Adenoma
Conditions
Brief summary
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.
Detailed description
Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.
Interventions
DRUGSevoflurane
1-1.5 MAC, inhalation route, during operation
DRUGDesflurane
1-1.5 MAC, inhalation route, during operation
DRUGPropofol
6-10 mg/kg/h, iv infusion, during operation
Sponsors
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists (ASA) score I-II patients
Exclusion criteria
* Significant cardiopulmonary disease, * Diagnosed obstructive or restrictive pulmonary disease, * Patients with chest wall deformities, liver or kidney failure, * Postoperative lack of cooperation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline FEV1%predicted (no unit) | Preoperative baseline, postoperative 1st hour and postoperative 24th hour | FEV1 is measured with spirolab III colour liquid-crystal-display medical spirometer. FEV1%predicted is calculated with age, sex, height and weight input by the same equipment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline FVC%predicted (no unit) | Preoperative baseline, postoperative 1st hour and postoperative 24th hour | FVC is measured with spirolab III colour liquid-crystal-display medical spirometer. FVC%predicted is calculated with age, sex, height and weight input by the same equipment. |
| Change from baseline FEV1/FVC ratio (no units) | Preoperative baseline, postoperative 1st hour and postoperative 24th hour | FEV1/FVC ratio is calculated by spirolab III colour liquid-crystal-display medical spirometer based on age, sex, height and weight. |
| Change from baseline PaO2 (mmHg) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | PaO2 is a component of arterial blood gas analysis done with Cobas B221. |
| Change from baseline pH | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | pH is a component of arterial blood gas analysis done with Cobas B221 |
| Change from baseline PaCO2 (mmHg) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | PaCO2 is a component of arterial blood gas analysis done with Cobas B221. |
| Change from baseline BE (mmol/L) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | BE is a component of arterial blood gas analysis done with Cobas B221 |
| Change from baseline HCO3 (mmol/L) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | HCO3 is a component of arterial blood gas analysis done with Cobas B221 |
| Change from baseline PaO2/FiO2 ratio (no units) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | PaO2/FiO2 ratio is calculated by investigators |
| Change from baseline SaO2 (%) | Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour | SaO2 is a component of arterial blood gas analysis done with Cobas B221 |
Countries
Turkey (Türkiye)
Contacts
Primary ContactAbdulvahap Oguz, MD
Outcome results
None listed