Alveolar Bone Loss
Conditions
Keywords
hyaluronic acid, bone repair, dental socket, cone beam computed tomography
Brief summary
The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.
Interventions
DRUGhyaluronic acid
OTHERPlacebo
Sponsors
Federal University of Minas Gerais
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
14 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Orthodontic need for bilateral extraction of lower first premolars
Exclusion criteria
* Alcoholism, smoking, drug use and abuse of drugs; Systemic diseases: uncontrolled diabetes, blood dyscrasias, kidney or heart failure and osteoporosis; clinical or radiographic signs of pathological processes in the bone;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of bone formation | 30 days after extraction and treatment application | During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation |
| Fractal dimension | 30 days after extraction and treatment application | During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image. |
| Dimensional Alveolar changes | 30 to 90 days after extraction and treatment application | To determine whether treatment could prevent loss of buccolingual thickness, was compared bone loss of 90 to 30 days between the treated and control groups. |
Outcome results
None listed