Labor Analgesia
Conditions
Keywords
β2-adrenergic receptor, genetic polymorphisms, labor progress
Brief summary
Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.
Interventions
GENETICβ2AR polymorphism
Sponsors
Nanjing Maternity and Child Health Care Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
23 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* Nulliparous women * Required labor analgesia * Chinese * Spontaneous labor
Exclusion criteria
* Contraindications for epidural analgesia * Allergic to opioids and/or local anesthetics * Failed to performing epidural catheterization * Organic dysfunction * Those who were not willing to or could not finish the whole study at any time * Using or used in the past 14 days of the monoamine oxidase inhibitors * Alcohol addictive or narcotic dependent patients * Subjects with a nonvertex presentation or scheduled induction of labor * Twin gestation and breech presentation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total labor process | up to about 24h | time from the regular uterus contractions until completed childbirth, assessed up to about 24h |
| duration of the first stage | up to about 20h | time from the regular uterus contractions to full cervix dilation,assessed up to about 20h |
| duration of the second stage | up to about 2h | time from full cervix dilation to the complete childbirth, assessed up to about 2h |
| Maternal visual analogue scale | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Use of oxytocin after analgesia | At twenty-four hours postpartum | At twenty-four hours postpartum |
| Neonatal Apgar scale | At the first and fifth minutes after baby was born | At the first and fifth minutes after baby was born |
| method of delivery | At time of placental delivery | At time of placental delivery |
| Maternal heart rate, respiratory rate, and blood pressure | At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours) | At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours) |
| Neonatal weight | At delivery | At delivery |
| Maximal oxytocin dose | At twenty-four hours postpartum | At twenty-four hours postpartum |
| Maternal modified Bromage scale | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) |
| Rescue boluses, n of rescue boluses, and the consumption of the ropivacaine/sufentanil mixture | At two hours postpartum | At two hours postpartum |
| Maternal satisfaction with analgesia | At two hours postpartum | At two hours postpartum |
Outcome results
None listed