Vascular Endothelial Growth Factor Overexpression
Conditions
Brief summary
The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.
Detailed description
Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters. One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.
Interventions
BIOLOGICALPRGF in candidates for sperm donors
PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.
Sponsors
bTI Vitoria
IVI Bilbao
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-35 years * more than 5 million sperm per milliliter
Exclusion criteria
* Not having genetic and infectious diseases * Do not suffer mental illness * Have a family study determined that there is no risk of hereditary diseases * There have fathered more than 6 children in the country
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added | 6 months | Within concerted donor visits in IVI Bilbao will be held: * Removing Blood 9 mL of blood to obtain plasma rich in factors growth * Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility. * Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility. |
Countries
Spain
Outcome results
None listed