Cardiac Arrest, Cardiopulmonary Arrest
Conditions
Keywords
Chest compressions, Cardiopulmonary Resuscitation, Pediatric
Brief summary
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Detailed description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal. Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
Interventions
None listed
Sponsors
Zoll Medical Corporation
Children's Hospital of Philadelphia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Patient received chest compressions for at least 1 minute * Patient between gestational age ≥37 weeks and 18 years of age
Exclusion criteria
* Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR | 10 Years | Primary outcome: Guideline-compliant CPR which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. Guideline-compliant CPR requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score. |
Countries
Australia, Brazil, Canada, Colombia, Italy, Japan, Netherlands, New Zealand, Singapore, South Korea, Spain, Taiwan, Thailand, United Kingdom, United States
Contacts
Primary ContactVinay Nadkarni, MD, MS
Backup ContactKathryn Graham
Outcome results
None listed