Sepsis
Conditions
Keywords
sepsis, biomarker, prognostic, emergency department, diagnosis
Brief summary
Monocentric prospective study on consecutive patients attending the emergency department and suspected to have sepsis. Blood sampling for the measurement of a panel of biomarkers of interest in sepsis.
Detailed description
The management of patients admitted to the emergency department (ED) requires investigative biological parameters that help clinicians to make the right diagnosis. Sepsis concerns patients with infection associated with a systemic inflammatory response. While this inflammatory profile is observed in many clinical situations in the ED, the challenge is to characterize in these patients suspected of sepsis those who have a real infection. Currently, no individual biomarker of sepsis is sufficiently discriminant. The objective of this study is to measure in patients suspected of sepsis in the emergency department, a combination of biomarkers (covering several distinct pathophysiological pathways) that could provide high specificity and sensitivity for the diagnostic and prognostic. The originality of this study is that compared with patients admitted to intensive care units, patients investigated for suspected sepsis in the ED are seen earlier in their medical history and usually before any therapeutic intervention (intravenous fluids, antibiotics, catecholamines) interfering with several biomarkers of interest.
Interventions
BIOLOGICALblood sampling
during the usual blood sampling performed in the ED in patients suspected of sepsis, two additional tubes will be sampled for a panel of biomarkers measurement
Sponsors
Institut Pasteur
Bio-Rad Laboratories
Pitié-Salpêtrière Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* patient attending the ED and suspected to have sepsis by the emergency physician after clinical exam
Exclusion criteria
* patient minor under 18-year * pregnancy * anticipated no follow-up possible (homeless...) * Refusal to participate * patient under curators, prisoner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sepsis diagnosis | 30-day after inclusion | Among the patients included in the study with a sepsis suspicion, the primary outcome measure will be a final diagnosis of sepsis adjudicated on the medical file and 30-day follow-up, by an expert panel blind for the biomarkers studied |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| severe outcome defined by: severe sepsis and/or septic shock and/or ICU admission and/or death in the 30-day follow-up | 30-day after inclusion | Among the patients included in the study with a sepsis suspicion, a diagnosis of severe sepsis and/or septic shock will be adjudicated on the medical file and 30-day follow-up by an expert panel blind for the biomarkers studied. ICu admission and death will be recorded by the medical file and 30-day phone interview. |
Countries
France
Outcome results
None listed