Alveolar Ridge Preservation, Extraction Socket Healing
Conditions
Brief summary
The goal of this project is to evaluate the influence of platelet rich fibrin (PRF) in extraction socket healing with or without particulate bone graft. The hypothesis of this study is that PRF will enhance the extraction socket healing and new bone formation when compared to extraction sockets grafted without PRF.
Interventions
PROCEDURESocket grafting with PRF
Extraction with socket grafting using PRF.
PROCEDURESocket grafting with bone graft
Extraction with socket grafting using bone graft.
Sponsors
The University of Texas Health Science Center, Houston
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects ≥ 18 years of age * Hopeless or non-restorable single non-molar tooth per quadrant with adjacent teeth present * Maximum of two teeth can qualify per patient. * The buccal plate must be ≥ 1mm in width with a 4-wall configuration. * Cases requiring minimal sinus grafting (\<3mm) * Bone grafting limited to the apical portion of the osteotomy site
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in alveolar ridge width (buccal-lingual) | baseline, 3 months | Baseline is at the time of extraction with or without socket grafting. |
| Change in alveolar ridge height (apical coronal) | baseline, 3 months | Baseline is at the time of extraction with or without socket grafting. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of vital bone in bone core as assessed histology | 3 months | A bone core will be taken at 3 months after socket grafting. |
| Percentage of residual bone graft in bone core as assessed histology | 3 months | A bone core will be taken at 3 months after socket grafting. |
Countries
United States
Outcome results
None listed