CLOPIDOGREL, POOR METABOLISM of (Disorder), Myocardial Ischemia
Conditions
Brief summary
This study evaluated epidemiology and clinical outcome of clopidogrel related various genotyping in Korean patients who had undergone percutaneous coronary intervention as a all comer registry form.
Detailed description
This study evaluates the relationship between clopidogrel related various genotyping, epidemiology and clinical outcome of patient who had undergone percutaneous coronary intervention. Clopidogrel resistance was measured with VerifyNow, which is a device that can monitor platelet inhibition of clopidogrel. Genes which are known to be related with clopidogrel resistance were evaluated; (1-3) CYP 2C19 \*2, \*3, \*17, (4) PON1 Q192R, (5) ABCB1 3435C-\>T, (6) P2Y12, (7) CYP 2C9 \*3.
Interventions
DRUGClopidogrel
Administration of conventional dual anti-platelet treatment (aspirin 100mg and clopidogrel 75mg daily) for minimum 3 months after percutaneous coronary intervention
Sponsors
Korea University Anam Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Written informed consent * Older than 20 years * All percutaneous coronary intervention patients within 1 month
Exclusion criteria
* Pregnancy * Life expectancy below 1 year * Known aspirin or clopidogrel allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial infarction and Death | 1 year after index procedure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac death | 1 year after index procedure | — |
| Myocardial infarction | 1 year after index procedure | — |
| Stent thrombosis (acute, late, very late) | 1 year after index procedure | — |
| Target lesion revascularization | 1 year after index procedure | Revascularization of in-stent restenosis which developed in previously implanted stent on index procedure |
| Any death | 1 year after index procedure | — |
| Bleeding complication | During index procedure | — |
| PRU | Within index procedure | Value which is measured with VerifyNow that can monitor platelet inhibition of clopidogrel |
| ARU | Within index procedure | Value which is measured with VerifyNow that can monitor platelet inhibition of aspirin |
| Stroke | 1 year after index procedure | Ischemic or hemorrhagic cerebral infarction diagnosed by brain MRI which developed within 1 year after index procedure |
Outcome results
None listed