Delirium, Inflammation, Insulin Resistance
Conditions
Brief summary
This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.
Detailed description
Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.
Interventions
DIETARY_SUPPLEMENTAllocated to Carbohydrated group
Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.
DIETARY_SUPPLEMENTAllocated to Placebo group
Patients received 400 mL of oral flavored water (Placebo) 12 hours before anesthesia and 400 mL 2 hours before
Sponsors
Gangnam Severance Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing total hip replacement or total knee replacement surgery
Exclusion criteria
* Diabetes * Dementia * Gastro-esophageal reflux * Upper gastrointestinal motility disorder * Inflammatory bowel disease * Intraperitoneal malignancy history * Inability to perform cognitive function test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum S-100β level | Postoperative 1 hr |
Outcome results
None listed