Anaesthesia, General, Anesthesia, Intravenous, Ventilation
Conditions
Brief summary
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing it into clinical practice. The general purpose of this project is to evaluate a new ventilation strategy during ENT-surgery based on oxygenation with high-flow nasal cannula with 100% oxygen with focus on gas exchange.
Interventions
PROCEDUREHyperventilation
Sponsors
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult, \>18 years old 2. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery) and the anesthesia time is \<40 mins. 3. Capable of understanding the study information and sign the written consent.
Exclusion criteria
1. ASA\>2 2. NYHA \>2 3. BMI \>30 4. Pregnancy 5. Manifest cardiac failure or coronary disease 6. Neuromuscular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in arterial carbon dioxide (pCO2) | From start of anaesthesia to end of apnoea oxygenation or max 30 minutes |
| Change in arterial pH | From start of anaesthesia to end of apnoea oxygenation or max 30 minutes |
| Change in arterial oxygen tension (pO2) | From start of anaesthesia to end of apnoea oxygenation or max 30 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pH in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation? | In the end of the apnoea period, i.e. at approximately 20 minutes |
| Does the high oxygen content cause atelectasis measures as change in relation between pCO2 and end tidal carbon dioxide | Until discharge from the postoperative unit, often max 2 hours |
| Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation? | In the end of the apnoea period, i.e. at approximately 20 minutes |
| Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pCO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation? | In the end of the apnoea period, i.e. at approximately 20 minutes |
Outcome results
None listed