Healthy, Hypertension, Pre-hypertension
Conditions
Brief summary
The purpose of this RCT which will be performed in 60 healthy adults is I. To assess the training effects of 8 weeks of isometric handgrip exercise on BP; and to test whether it yields at least similar effects on BP compared to current exercise recommendations. II. To assess whether isometric handgrip training yields larger BP reductions beyond the supervised training period at 6 months of follow-up. III. To determine whether changes in BP following acute exercise and chronic training can be explained by changes in important physiological mechanisms known to mediate or to be associated with BP?
Interventions
Participants have to perform 4 x 2 minute contractions with alternating hands, separated with 1 minute rest period using a ZonaHealth device;
To perform 150 minutes extra/week at moderate aerobic intensity
Sponsors
Research Foundation Flanders
KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* not physically active (\< 3 hours of moderate to high levels of PA/week) low cardiovascular risk according to current guidelines (Mancia et al J Hypertens 2013) will be recruited through advertisements. The latter is defined as: * \>115 mmHg \< systolic BP \< 139 mmHg and/or 75 mmHg\< diastolic BP\<90mmHg in the presence of 0 to a maximum of three other cardiovascular risk factors, excluding diabetes Or * 139 mmHg \< systolic BP \< 160 mmHg and/or 90 mmHg\<DBP\< 100 mmHg in the absence of other cardiovascular risk factors
Exclusion criteria
* current smoker * pregnancy * presence of other cardiovascular disease, pulmonary disease or metabolic disease * inability to perform a standard exercise program due to mental/physical disability. * use of antihypertensive drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in office blood pressure at 8 weeks of follow-up | 8 weeks - 6 months |
Secondary
| Measure | Time frame |
|---|---|
| change in exercise tolerance (peakVO2 in ml/min/kg) at 8 weeks of follow-up | 8 weeks - 6 months |
Countries
Belgium
Outcome results
None listed