IgY Efficacy on Periodontitis Patients

Evaluation of IgY Antibody Effectiveness in Supportive Therapy of Periodontitis Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02705885

Enrollment

Registered

2016-03-11

Start date

2014-06-30

Completion date

2015-03-31

Last updated

2016-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Keywords

IgY, Periodontitis, Porphyromonas gingivalis, gingipains, Efficacy

Brief summary

Patients visiting National Hospital of Odonto-Stomatology for treating periodontitis used a food supplement (lozenge) containing chicken egg antibody (IgY) against Porphyromonas gingivalis gingipains as an adjunct to conventional scaling and root planing (SRP). After 8 weeks the patients were examined against. Parameters including probing depth (PD), bleeding on probing (BOP), number of P. gingivalis in periodontal pockets were evaluated and compared to the control group that had used placebo lozenges.

Interventions

DIETARY_SUPPLEMENTlozenges containing IgY

Patients consumed food supplement lozenges containing IgY after nonsurgical periodontal therapy

DIETARY_SUPPLEMENTPlacebo IgY

Placebo IgY

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* patients diagnosed with chronic periodontitis * had at least 2 interproximal site with pocket depth between 3 mm to 5 mm * nonsmokers with at least 20 natural teeth * bone loss and bleeding on probing * had not undergone periodontal treatments within 6 weeks before the study

Exclusion criteria

* patients received medication such as antibiotics or anti-inflammatory drugs within the previous 3 months * had allergy to egg proteins

Design outcomes

Primary

Measure	Time frame	Description
Effect of anti-gingipain IgY on probing pocket depth of subjects with chronic periodontitis	8 weeks	Outcome measurement is probing pocket depth (PD)
Effect of anti-gingipain IgY on bleeding on probing of subjects with chronic periodontitis	8 weeks	Outcome measurement is bleeding on probing (BOP)

Secondary

Measure	Time frame	Description
Effect of anti-gingipain IgY on Porphyromonas gingivalis level of subjects with chronic periodontitis	8 weeks	Outcome measurement is P. gingivalis level in periodontal pockets

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026