Cardiomyopathies, Microcirculation, Microvessels
Conditions
Keywords
index of microvascular resistance
Brief summary
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at the IMR (index of microcirculatory resistance) assessment
Detailed description
The Authors will enroll at the moment of coronary artery angiography patients without history of ischemic heart disease and new diagnosis (at transthoracic echocardiography) of left ventricular dilation. All patients will undergo coronary artery angiography. To be enrolled, it is necessary to have the absence of significant coronary artery stenosis (angiographic evaluation of the lesion \>40%) in all the vessels (main and side branch). The Authors will proceed to perform the evaluation of the index of microvascular resistance (IMR). The target vessel will be the left anterior descending artery. An intracoronary pressure/temperature sensor-tipped guidewire will be used. Thermodilution curves will be obtained during maximal hyperemia. The IMR will be calculated from the ratio of the mean distal coronary pressure at maximal hyperemia to the inverse of mean hyperemic transit time.
Interventions
PROCEDUREindex of microvascular resistance
Measurement of the index of microvascular resistance in the left anterior descending artery
Sponsors
University Hospital of Ferrara
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* new diagnosis of left ventricular dilation (dilatative cardiopathy) * absence of significant (\>40%) coronary artery disease at coronary artery angiography
Exclusion criteria
* history of ischemic heart disease * history of significant valvular disease * contraindication to hyperemic agent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Index of microcirculatory resistance | during coronary artery angiography | Measurement of IMR in the left anterior descending artery of patients with new diagnosis of left ventricular dilatation and no significant stenosis in epicardial coronary arteries |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cardiac death | 1-year | occurrence of cardiac death at 1 year |
Other
| Measure | Time frame | Description |
|---|---|---|
| all-cause death | 1-year | occurrence of all-cause death at 1 year |
| heart failure | 1-year | occurrence of hospital admission for heart failure |
Countries
Italy
Outcome results
None listed