Lateral Postural Inclination in Parkinson's Disease : Involvement of the Basal Ganglia ?

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02704910

Acronym

IPOLAP

Enrollment

Registered

2016-03-10

Start date

2012-01-31

Completion date

2015-06-30

Last updated

2016-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Brief summary

The objective of this study is to assess the origins of lateral postural inclination presented by some Parkinson disease's patients. Several mechanisms could cause lateral postural inclination. Available data allow to suggest three hypothesis: (troubles of tonus, perception of vertical perturbation, trouble of perception of corporal axis

Detailed description

Inclusion Criteria: * 30 to 75 years old patient * Parkinson disease's diagnosed since 5 years * Treated by deep brain stimulation * Patient with at least 6 degree lateral deviation * Without vestibular troubles nor peripheral sensorial trouble. Exclusion Criteria: * Dementia (Mattis \< 130 ou MMS \<24), or severe depressive episode according to DSM IV-R criteria * Camptocormia or incompatible anteflexion with the dispositive of measure device * Pregnant woman, nursing mother

Interventions

BEHAVIORALSubthalamic stimulation

Assess difference of amplitude (in degree) of the postural deviation between both condition of unilateral condition of subthalamic nucleus

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

30 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* 30 to 75 years old patient * Parkinson disease's diagnosed since 5 years * Treated by deep brain stimulation * Patient with at least 6 degree lateral deviation * Without vestibular troubles nor peripheral sensorial trouble.

Exclusion criteria

* Dementia (Mattis \< 130 ou MMS \<24), or severe depressive episode according to DSM IV-R criteria * Camptocormia or incompatible anteflexion with the dispositive of measure device * Pregnant woman, nursing mother

Design outcomes

Primary

Measure	Time frame	Description
Lateropulsion measured by computerized Posturography	4 days	The postural inclination is measured in two conditions: With and without Deep Brain Stimulation. (Gissot et al., 2007).

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026