Parkinson Disease
Conditions
Keywords
Parkinson disease, Deep brain stimulation, Freezing of Gait
Brief summary
Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease
Detailed description
Unilateral modulation of subthalamic stimulation and its impact on freezing of gait in Parkinson's disease will be studied. In a cross-over, doubleblind, randomized study, a 30% reduction of stimulation intensity of the less impacted side will be compared with chronic treatment with regard to frequency and duration of freezing of gait episodes.
Interventions
PROCEDUREUnilateral reduction of stimulation
30% unilateral reduction of Subthalamic nucleus stimulation
PROCEDUREChronic Subthalamic nucleus stimulation
This arm is the reference, with the best stimulation parameters
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patients affiliated to social security Patient with idiopathic parkinson's disease, with deep brain stimulation since at least one year Freezing of gait Able to give inform consent
Exclusion criteria
Patient under guardianship, legal guardianship Psychosis Severe depression Severe cognitive troubles (Mattis \< 130) Other neurologic or medical pathology interfering with gait
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| improvement of Freezing of gait | 1 month after new stimulation parameters | the improvement will be measure with a composite score of items 12 + 13 on UPDRS II and items 10+11 on UPDRS III, |
Countries
France
Outcome results
None listed