Hyperglycemia
Conditions
Brief summary
Amylose-amylopectin ratio may influence the rate of starch digestion. This randomized controlled study evaluated the postprandial metabolic effects of amylose-rich- wheat- based rusks in overweight subjects.
Interventions
OTHERTest meal
Participants received in random order a test meal (900Kcal, 100g carbohydrates) containing rusks prepared with amylose-rich wheat flour or conventional flour. Blood samples were collected at fasting and every 30 minutes over 4 hours. Breath hydrogen was evaluated as a marker of intestinal fermentation. Participants underwent Visual Analogue Scale to assess subjective appetite sensations.
Sponsors
Federico II University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight/obese; * 30-60 years.
Exclusion criteria
* age \<30 and \>60 years; * fasting triglycerides ≥400 mg/dl; * fasting cholesterol \>270 mg/dl; * cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study; * established diabetes mellitus or any chronic disease; * renal and liver failure (creatinine \>1.7 mg/dl and transaminases \>2 times than normal values, respectively); * anaemia (Hb \<12 g /dl); * any chronic disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose | 4 hours | Incremental area under the curve |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood insulin | 4 hours | Incremental area under the curve |
| Intestinal fermentation | 4 hours | Incremental area under the curve |
| Blood triglycerides | 4 hours | Incremental area under the curve |
Countries
Italy
Outcome results
None listed