Type 2 Diabetes Mellitus
Conditions
Brief summary
With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community. Particular attention has been drawn to various benefits of replacing saturated fatty acids with unsaturated fatty acids. Alpha-linolenic acid, the only omega-3 fatty acid that is from plant sources, has been suggested by animal and cell studies to play a beneficial role in regulating blood glucose levels. However, human studies have been more inconsistent with their findings. The focus of this project is to investigate the evidence in the context of ALA and blood glucose parameters in participants with type 2 diabetes by conducting a systematic review and meta-analysis of randomized controlled trials.
Interventions
DIETARY_SUPPLEMENTAlpha-Linolenic Acid
Meta-Analysis of Randomized Controlled Trials
Sponsors
Unity Health Toronto
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Controlled, randomized, clinical trials * Trials greater than one month * Focusing on ALA and T2DM participants * Viable endpoint data
Exclusion criteria
* Non-human studies * Non-random treatment allocation * Less than 1 month * Lack of suitable control * Lack of endpoint data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Fructosamine | 1 month |
| Fasting Blood Glucose | 1 month |
| Fasting Blood Insulin | 1 month |
| Glycated Albumin | 1 month |
| HOMA- IR | 1 month |
Outcome results
None listed