Non-linear Multimodal Microendoscopy for Lung Cancer Pathology

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02699229

Enrollment

Registered

2016-03-04

Start date

2024-01-11

Completion date

2024-12-03

Last updated

2024-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer

Brief summary

For this study the investigators are looking to do the following: 1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues. 2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue.

Detailed description

For this study the investigators are looking to do the following: 1. To characterize human lung lesions by nonlinear microscopy using ex vivo tissues. In particular, to investigate collagen content and ultrastructure with SHG (second harmonic generation) microscopy, to characterize cell and nuclear morphology and lipid vesicle content with THG (third harmonic generation) and CARS (coherent anti-Stokes Raman scattering) microscopy and to conduct spectroscopic and lifetime characterization of MPF (multiphoton fluorescence) signals in cancerous, benign, and normal tissues. 2. To establish the first spectral/structural database for nonlinear optical microimaging of normal and abnormal lung tissue, from which to generate diagnostic algorithms, both to optimize the operating parameters of planned nonlinear endoscopic imaging and to serve as the basis for nonlinear optical histopathology.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years or older. * Patients with confirmed or suspected lung cancer who require lobectomy as part of standard-of-care.

Exclusion criteria

* Patients deemed on clinical grounds not to be medically fit for a lobectomy * Patients where there is a high clinical suspicion of lymphoma (to avoid mixing the data sets). * Patients unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Nonlinear optical microscopy for cancerous tissue detection in human lung lesions	Two years

Secondary

Measure	Time frame
The first spectral/structural database for nonlinear optical micro-imaging of normal and abnormal lung tissue	Two Years

Outcome results